Do not take cisapride if you have heart disease or hardening of the arteries, heart failure, an irregular heartbeat or a history of irregular heartbeats, a history of prolonged QT intervals, a family history of congenital long QT syndrome, a slow heart rate that is considered a medical condition, a structural heart defect, heart block or other conduction disturbances, severe dehydration (loss of water), vomiting, malnutrition, an eating disorder, or kidney failure. These conditions may increase the risk of irregular heartbeats, heart attack, and death while taking cisapride.

Furthermore, do not take cisapride with any of the following drugs: antibiotics such as clarithromycin (Biaxin®), erythromycin (Ery-Tab®, E.E.S.®, E-Mycin®, others), troleandomycin (TAO®), and sparfloxacin (Zagam®); antidepressants such as amitriptyline (Elavil®), maprotiline (Ludiomil®), and nefazodone (Serzone®); antifungal medications such as fluconazole (Diflucan®), itraconazole (Sporanox®), and ketoconazole (Nizoral®); phenothiazines such as prochlorperazine (Compazine®, others) and promethazine (Phenergan®, others); antihistamines such as astemizole (Hismanal®); blood pressure medications such as bepridil (Vascor®); heart medications such as procainamide (Procan SR®, Procanbid®, Pronestyl®) and quinidine (Quinidex®, Quinaglute®); and HIV medications such as indinavir (Crixivan®) and ritonavir (Norvir®). Taken with any of these drugs, cisapride may cause irregular heartbeats that could lead to death. Nevertheless, this is not a complete list of drugs that may interact with cisapride and cause heart problems. Talk to your doctor or pharmacist before taking any other medications.

Additionally, cisapride is in the FDA pregnancy category C. This means that it is not known whether cisapride will harm an unborn baby. Do not take cisapride without first talking to your doctor if you are pregnant.

Furthermore, cisapride passes into breast milk. It is not known whether cisapride will harm a nursing infant. Do not take cisapride without first talking to your doctor if you are breast-feeding a baby.

Use alcohol in moderation. Alcohol may increase drowsiness and dizziness while you are taking cisapride.

Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products may increase amount of cisapride available in your body, which could lead to dangerous side effects. 

 

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